Formulation Development of Celecoxib Loaded Microsponges using Eudragit and Ethyl Cellulose

Background: Microsponge is a class of dosage form containing porous nature drug that targeted to achieve sustained action for prolong period. based delivery system results in localization on skin surface and epidermis without moving systemic circulation higher extent. Methods: Present study aims formulate the microsponge celecoxib by quasi emulsification solvent diffusion method. Prepared formulations were evaluated particle size, % entrapment efficiency, production yield, morphology, etc. Results: Formulation F1 E2 considered as optimized formulation having loading 91±4.2 91±3.1 respectively. FTIR spectroscopy analysis indicated chemically stable, crystalline these microsponges. Small change crystallinity pure was observed XRD study. SEM shows good appearance with pores surfaces. Average size found be 48 μm while gave microsponges 33.7 μm. As RPM increased microsponge’s also decreased formed spherical uniform nature. Conclusion: Finally it can concluded microspheres using Eudragit L-100 Ethyl cellulose.